Addison's Disease Endocrine Disease - Lesson 327

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Addison's disease is an abnormal condition of less secretion of mineralocorticosteroids and glucocorticosteroids, especially less production of hormones produced by kidneys. Addison's disease happens when adrenal glands (glands above kidneys) produce less hormones, such as corticosteroids and aldosterone. The main reason for this disease is TB, any metastatic tumors or bilateral hemorrhage.

Adrenal Gland Hormones:  The glands produce hormones that are above kidneys are call adrenal glands. The outer area of an adrenal gland is called as cortex and the inner area of an adrenal gland is medulla. The main reason for the Addison's disease is less formation of adrenal cortex hormones. The names of adrenal cortex hormones are cortisol, aldosterone, androgen and estrogen.  Cortisol helps to maintain sugar in our body and immune response; aldosterone helps to regulate minerals, such as sodium and potassium in the blood. Androgen and estrogen are male and female sex hormones that are important for gender characteristics and development.

Cause of Addison's Disease:  For any reasons, if the adrenal cortex is affected, they may start to produce cortisol, aldosterone, androgen or estrogen and so Addison's disease happens. A disease called TB or HIV or tumors or blood loss may happen this damage to the adrenal cortex.

Symptoms of Addison's Disease:  The formation of less sugar in blood called hypoglycemia, less sodium in blood called hyponatremia, body weakness, weight loss, formation of dark pigments on the skin are the main symptoms of Addison's disease.

Treatment:  Abdominal CT scans and abdominal x-rays are helpful in diagnosing Addison's disease. A blood count check and mineral checks are important to diagnose this abnormal condition. Hormone replacement is the best treatment type of this.

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In the next lesson, we will see about diabetes mellitus. Okay. Come on.

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