CARDIAC-LAB CHEMISTRY-LESSON 140
Cardiac Creatine phosphokinase (CK) - Levels rise 4 to 8 hours after an acute MI, peaking at 16 to 30 hours and returning to baseline within 4 days 25-200 U/L 32-150 U/L CK-MB CK isoenzyme - It begins to increase 6 to 10 hours after an acute MI, peaks in 24 hours, and remains elevated for up to 72 hours. <>400 IU/L (LDH) Lactate dehydrogenase - Total LDH will begin to rise 2 to 5 days after an MI; the elevation can last 10 days. 140-280 U/L LDH-1 and LDH-2 LDH isoenzymes - Compare LDH 1 and LDH 2 levels. Normally, the LDH-1 value will be less than the LDH-2. In the acute MI, however, the LDH 2 remains constant, while LDH 1 rises. When the LDH 1 is higher than LDH 2, the LDH is said to be flipped, which is highly suggestive of an MI. A flipped pattern appears 12-24 hours post MI and persists for 48 hours. LDH-1 18%-33% LDH-2 28%-40% SGOT - will begin to rise in 8-12 hours and peak in 18-30 hours 10-42 U/L Myoglobin - early and sensitive diagnosis of myoc